A pilot randomised controlled trial of psychological treatment selection for depression.
TherapyMatch-D app study is sponsored by Rotherham, Doncaster and South Humber NHS Foundation Trust. It aims to pilot the effectiveness of an artificial intelligence (AI) treatment selection model to improve clinical outcomes (for example, reduce depression) in adults accessing high intensity psychological therapies for depression in primary mental health services relative to allocation to these two therapies as usual.
We want to explore if matching certain subgroups of people with depression to a particular therapy would help patients. Two therapies for depression routinely offered in talking therapy sites are cognitive behavioural therapy (CBT), and person-centred experiential therapy (PCE), also known as counselling for depression. Both therapies are equally effective.
The app will enable therapists in the intervention group to make a personalised treatment recommendation, and as part of shared decision-making. Those in the control group will simply use the app as a data collection tool.
Recruitment end date, 1 August 2026.
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Published: September 23, 2025